Fatty live disease
Conditions
Interventions
Gold Standard:Hepatic Histopathology and/or Magnetic resonance-proton density fat fraction.
Index test:Utilizing the Mindray Resona color Doppler diagnostic system, the multiparametric quantitative analysis for hepatic fat content was activated. The novel technologies include:
UltraSound Att
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age >=18 years 2. Sonographic evidence of hepatic fat infiltration 3. Unexplained liver enzyme abnormalities 4. Patients with: - Obesity - Hypertriglyceridemia - Type 2 diabetes mellitus (T2DM) - Hypertension - Hyperuricemia - Chronic alcohol consumption* (*Per 2019 Chinese Expert Recommendations on Standardized Diagnosis/Treatment of Fatty Liver Disease) 5. Asymptomatic individuals undergoing: - Partial hepatectomy for non-SLD conditions (e.g., hepatic hemangioma, FNH resection) - Liver biopsy for unrelated disorders
Exclusion criteria
Exclusion criteria: 1. Liver transplant recipients 2. Pregnant or lactating women 3. Patients with severe respiratory insufficiency unable to cooperate with breath-holding 4. Cases declining MRI-PDFF examination
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area Under the Receiver Operating Characteristic Curve (AUC) of the Multiparametric Ultrasound Model for Steatosis Grading;Sensitivity and Specificity in the Validation Cohort; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pearson Correlation Coefficients (r-values) Between Multiparametric Ultrasound Indices and MRI-PDFF;Intergroup Differences of Multiparametric Ultrasound Parameters Across Steatosis Grades (S0-S3);Goodness-of-Fit (R2) of the Multiparametric Linear Regression Model;Positive Predictive Value (PPV) and Negative Predictive Value (NPV) in the Validation Cohort; | — |
Countries
China
Contacts
Public ContactDesheng Sun
Peking University Shenzhen Hospital
Outcome results
None listed