Severe Pneumonia
Conditions
Interventions
observation group:None
Sponsors
TheThird People's Hospital of Chengdu
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Definition of severe pneumonia. Meeting the diagnostic criteria for severe community-acquired pneumonia (SCAP) per the 2007 IDSA/ATS guidelines: fulfillment of 1 major criterion or =3 minor criteria.Major criteria include: (1) Respiratory failure requiring invasive mechanical ventilation; (2) Septic shock with persistent need for vasopressors despite adequate fluid resuscitation. Minor criteria include: (1) Respiratory rate >30 breaths/min; (2) Oxygenation index (PaO2/FiO2) 20 mg/dL; (6) Leukopenia (WBC =3, with indications for parenteral nutrition (when oral/enteral nutrition is unfeasible, insufficient, or contraindicated), hemodynamically stable, and eligible for nutritional support; 3.Aged 18–80 years (male or female); 4. Written informed consent must be obtained from the participant or their legal guardian prior to enrollment.
Exclusion criteria
Exclusion criteria: 1. Severe pneumonia patients with anticipated mortality within 48 hours of ICU admission; 2. Patients with contraindications to parenteral nutrition; 3. Presence of general intravenous fluid contraindications during screening period; 4. Known hypersensitivity to egg or soy protein, peanut protein, any active ingredient/excipient in the investigational product formulation, or fish oil-based lipid emulsion; history of drug allergies or allergic constitution; 5. Severe hyperlipidemia; recent myocardial infarction or stroke; severe hepatic or renal dysfunction; 6. Pregnant or lactating women; 7. Patients deemed by investigators to have any other factors unsuitable for trial participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prealbumin before treatment;Albumin before treatment;Prealbumin after treatment;Albumin after treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lymphocyte count before treatment;Oxygenation index or oxygen saturation before treatment;Intravenous catheter-related fever;hospitalization time in ICU;Oxygenation index or oxygen saturation after treatment;Lymphocyte count after treatment; | — |
Countries
China
Contacts
Public ContactWei Zeng
TheThird People's Hospital of Chengdu
Outcome results
None listed