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A retrospective cohort study on the efficacy of inositol and metformin in spontaneous abortion patients with insulin resistance

A retrospective cohort study on the efficacy of inositol and metformin in spontaneous abortion patients with insulin resistance

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500106507
Enrollment
Unknown
Registered
2025-07-24
Start date
2025-08-20
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Insulin resistance

Interventions

Inositol group:None
Control group:None
Metformin group:None

Sponsors

Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. 20 years old<=age<=45 years old; 2. History of pregnancy loss, including biochemical pregnancy; 3. OGTT and INS before or in the first trimester; 4. Treatment with metformin or inositol before or during pregnancy; 5. Complete medical records.

Exclusion criteria

Exclusion criteria: 1.Systemic infectious diseases; 2.Congenital uterine malformation (unicornuate uterus, bicornuate uterus, septate uterus, etc.); 3.Previous History of diabetes mellitus; 4.Both spouses had chromosomal abnormalities.

Design outcomes

Primary

MeasureTime frame
Early abortion rate;—

Secondary

MeasureTime frame
HOMA-IR;The incidence rate of common complications during pregnancy;BMI;Incidence of adverse reactions;Delivery situation;—

Countries

China

Contacts

Public ContactChen Hui

Sun Yat-sen Memorial Hospital, Sun Yat-sen University

zheling76@163.com+86 20 8133 2587

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026