Cardiovascular and cerebrovascular diseases, chronic kidney diseases
Conditions
Interventions
Sponsors
Third People's hospital of Dalian
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Clearly diagnosed coronary heart disease, including previously clearly diagnosed myocardial infarction, having received coronary intervention therapy or coronary artery bypass grafting treatment, coronary artery stenosis>=50%, or chest pain with objective evidence of myocardial ischemia (stress electrocardiogram or stress imaging examination suggesting myocardial ischemia). 2.A clearly diagnosed stroke. 3.Individuals who do not meet either 1. or 2. but are at high risk of cardiovascular and cerebrovascular diseases are defined as having at least two of the following risk factors: (1) Male aged 60 or above, or female aged 65 or above; (2) Diabetes (3) Hypertension (4)Total cholesterol > 5.2 mmol/L, or LDL-C > 3.4 mmol/L, or HDL-C =28 kg/m2;(6)Smoking, defined as currently smoking every day for one year or more; 4.Chronic kidney disease (CKD) must meet any one of the following conditions and last for more than 3 months: (1) Signs of kidney injury, presenting any of the following: 1) Albuminuria: Urinary albumin excretion rate (UAER)>=30 mg/24 h or urinary albumin/creatinine ratio (UACR) >=30 mg/g. Abnormal urine sediment. Tubule-related lesions. 2) Histological abnormalities of the kidneys. Structural abnormalities were found in renal imaging examinations. 3) History of kidney transplantation. (2)Decreased glomerular filtration rate (GFR) 1) Estimated glomerular filtration rate (eGFR) <60 ml/min/1.73m² 2)If the duration of renal injury or abnormal renal function is unclear, CKD is diagnosed through clinical assessment.
Exclusion criteria
Exclusion criteria: 1. Due to individual's own reasons, they are unable to collect fundus imaging data that meets the research requirements: (1) Those with opacity of refractive media, severe macular edema, fundus hemorrhage, severe non-proliferative diabetic retinopathy (NPDR), retinal proliferation, severe epiretinal membrane pulling on blood vessels and causing deformation, etc., which affect the collection of fundus data(2)Those who have received retinal laser treatment in the past, or have received injection treatment in one eye, or have a history of vitreoretinal surgery(3)Those who cannot cooperate to complete the collection of the required fundus imaging data: such as Parkinson's disease, etc.(4)Other situations that prevent the collection of fundus imaging data that meets the research requirements; 2. Suffering from other serious diseases with an expected survival period shorter than one year, such as advanced malignant tumors, etc. 3. Unable to persist in long-term follow-up; 4. Other situations that researchers consider inappropriate for participation in the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood flow density in the macular area;CVI; | — |
Secondary
| Measure | Time frame |
|---|---|
| pressure;optometry;visual acuity;cardiovascular and cerebrovascular events;renal insufficiency events; | — |
Countries
China
Contacts
Public ContactYuanyuan Qi
Third People's hospital of Dalian
Outcome results
None listed