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Low-Dose Spinal Anesthesia Combined with Thoracic Epidural Anesthesia Reduces Hypotension After Spinal Anesthesia in Cesarean Delivery: A Randomized Controlled Study

Application of the Combined Spinal-Epidural Dual-Site Technique with Low-Dose Spinal Anesthesia via the Midline Epidural Approach in Cesarean Section

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500106489
Enrollment
Unknown
Registered
2025-07-24
Start date
2025-07-29
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None

Interventions

conventional - dose spinal - epidural anesthesia group:2–2.5 mL of 0.5% ropivacaine administered intrathecally (SA)
low - dose anesthetic spinal - epidural anesthesia with two puncture points group:Epidural anesthesia performed at T11–L2 or T12–L1, combined with 1.2–1.4 mL of 0.5% ropivacaine injected intrathecally

Sponsors

The First People's Hospital of Foshan
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Elective cesarean section 2. Age >=18 years old, <=45 years old 3. ASA grade I.~II. 4. Mothers and their families voluntarily participate and sign the informed consent form

Exclusion criteria

Exclusion criteria: 1. Absolute or relative contraindications to intrathecal anesthesia, such as coagulation disorders, central nervous system diseases, history of lumbar spine surgery, or infection at the puncture site. 2. Conditions such as gestational hypertension, pre-eclampsia, eclampsia, or intrauterine fetal distress. 3. A history of allergy to local anesthetics. 4. Dysfunction of critical organs such as the heart, liver or kidneys. 5. Psychiatric diseases.

Design outcomes

Primary

MeasureTime frame
the incidence of post - anesthesia hypotension;

Secondary

MeasureTime frame
The incidence severe post - anesthesia hypotension; Dosage of vasoactive agents use during the operation;The number of patients need vasoactive pharmacotherapy;Number of patients receiving esketamine during operation;Duration from induction of anesthesia to the start of surgery;Abdominal muscle relaxation dgree;Incidence of nausea, vomiting, and chills during the surgery;Apgar Scores of neonatal ;umbilical arterial blood gas;Duration of postoperative lower extremity motor block;VAS scores at rest or walking;The parturient’s satisfaction of the anesthesia ;

Countries

China

Contacts

Public ContactXueqing Zheng

The First People's Hospital of Foshan

1049550363@qq.com+86 180 3886 2202

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026