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The effect of intravenous esketamine combined nebulization with dexmedetomidine on the quality of recovery in children undergoing tonsilomy day-surgery

The effect of intravenous esketamine combined nebulization with dexmedetomidine on the quality of recovery in children undergoing tonsilomy day-surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500106471
Enrollment
Unknown
Registered
2025-07-24
Start date
2025-07-28
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Quality of postoperative recovery

Interventions

Combined atomization group1:Combined atomization group 1: After the operation, the same dose of saline was given intravenously as a placebo control,give 1µg/kg dextrometomidine atomization inhalation
Combined atomization group 2:Combined atomization group 2: After the operation, the same dose of saline was given intravenously as a placebo control,give 0.5µg/kg dextrometomidine atomization inhalati
Intravenous control group:Intravenous control group: 1µg/kg dextrometomidine was given intravenously after the operation, and the same dose of physiological saline was atomized and inhaled after extub

Sponsors

The First Affiliated Hospital of Anhui Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
6 Years to 15 Years

Inclusion criteria

Inclusion criteria: 1. Signed informed consent; 2. Children with elective day tonsillectomy surgery; 3. Age 6-15 years old; ASA grade I~II.

Exclusion criteria

Exclusion criteria: 1. Children with increased intracranial pressure or intraocular pressure; 2. Those who have any emotional disorders or mental illnesses; 3. Bradycardia or with heart block; 4. Those who have contraindications to the test drug and other anesthetic drugs.

Design outcomes

Primary

MeasureTime frame
Throat pain score 24h after surgery;

Secondary

MeasureTime frame
Degree of postoperative sedation;Delirium during awakening from anesthesia in children;Incidence of adverse events in 24 hours;Operation time;Anesthesia time;Wake-up time;Extubation time;PACU duration;Eating time;Length of hospitalization;Incidence of nausea and vomiting;Incidence of hypoxemia (SpO2<94%);Incidence of laryngeal spasm;Incidence of laryngeal spasm;

Countries

China

Contacts

Public ContactCheng Xinqi

The First Affiliated Hospital of Anhui Medical University

ay_mz_cheng@126.com+86 139 6501 5671

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026