Patients with esophageal cancer, stomach cancer, colorectal cancer, and liver cancer
Conditions
Interventions
Control group:Target-directed fluid therapy infusion Ringer test fluid maintenance
Treatment group:On the basis of goal-directed fluid therapy, it intervenes in plasma osmolarity
Sponsors
Chongqing University Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Patients or their family members agree and sign the informed consent form; 2.Patients aged 18-75 years old, ASA grade ?, grade ?; 3.Scheduled for major abdominal surgery (tumor resection, level-four surgery), including radical surgery for esophageal cancer, gastric cancer, colorectal cancer, and liver cancer; 4.Preoperative cardiac and pulmonary function is normal or mildly impaired (ejection fraction EF > 45%, arterial blood gas analysis with oxygen partial pressure > 70 mmHg, and normal carbon dioxide partial pressure).
Exclusion criteria
Exclusion criteria: 1.Patients undergoing emergency surgery; 2.Preoperative severe cardiac and pulmonary insufficiency, liver and kidney dysfunction (bilirubin > 2 times the normal value, transaminase > 3 times the normal value, creatinine > 117 umol/L, creatinine clearance rate > 50%), coagulation dysfunction (prolonged T > 3 seconds), fever, infection, etc. 3.Patients who have already undergone fluid management interventions preoperatively; 4.Participating in other clinical trials;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma osmolarity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stroke Volume Variation; | — |
Countries
China
Contacts
Public ContactHaijian Shen
Chongqing University Cancer Hospital
Outcome results
None listed