Bilateral Deep Cervical Lymphaticovenous Anastomosis for Moderate-to-Severe Alzheimer’s Disease: A Single-Center, Single-Arm, Bidirectional Observational Study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2500106464

Enrollment

Unknown

Registered

2025-07-24

Start date

2025-08-01

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer’s disease

Interventions

DCLVA group:NA

Eligibility

Sex/Gender

All

Age

50 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Age 50–85 years and having undergone bilateral deep cervical lymphaticovenous anastomosis; diagnosis of moderate-to-severe AD confirmed by the 2018 NIA-AA criteria; 2. Able to comply with all study-required follow-up assessments; 3. Life expectancy > 12 months; 4. Voluntary participation, willingness to provide biological specimens, and signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Alzheimer’s disease patients with concomitant type 2 diabetes mellitus; 2. History of hypersensitivity or contraindication to iodinated contrast agents; 3. Concurrent enrollment in any other interventional clinical trial (observational studies, natural-history and/or epidemiological studies lacking intervention are permitted); 4. Any additional condition that, in the judgment of the investigator or sponsor, renders the subject unsuitable for inclusion.

Design outcomes

Primary

Measure	Time frame
Neuropsychological assessment;	—

Secondary

Measure	Time frame
Postoperative complications;AD biomarkers;Imaging;	—

Countries

China

Contacts

Public ContactXiwen Ma

Zhengzhou Central Hospital

zbdywk@126.com+86 155 1596 4198

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026