Lung Cancer
Conditions
Interventions
intervention group:The intervention group will receive an 8- to 12-week exercise training program in addition to standard care.
control subjects:The control group will receive standard care, including regular health education based on routine treatment. The health education will cover topics such as balanced diet, lifestyle mo
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Newly diagnosed NSCLC stage IB–IIIB (N2); 2. Age >=18 years; 3. Patient has been evaluated by a multidisciplinary team and is scheduled to receive neoadjuvant immunotherapy or chemoimmunotherapy (PD-1/PD-L1 inhibitors) followed by surgery; 4. Body Mass Index (BMI) >=18.5 and self-reported weight loss <10% within the past month; 5. ECOG performance status (PS) <=2; 6. No contraindications to exercise training, such as myocardial infarction or stroke within the past 6 months, chronic heart failure, unstable angina, severe arrhythmias, significant left ventricular dysfunction, acute pulmonary embolism, severe peripheral vascular disease or limb dysfunction; 7. Willingness to participate and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Evidence of distant metastasis or other malignancies on imaging; 2. Inability to cooperate due to mental illness, consciousness disorder, or cognitive impairment; 3. Unable to tolerate exercise training; 4. Presence of any contraindications to physical activity (e.g., myocardial infarction or stroke within 6 months, chronic heart failure, unstable angina, severe arrhythmias, significant left ventricular dysfunction, acute pulmonary embolism, severe peripheral vascular disease or limb dysfunction); 5 Other exercise-related contraindications such as active hemoptysis or untreated pneumothorax; 6. Pregnant or breastfeeding individuals; 7. Unwillingness or inability to comply with study requirements; 8. Daily activity level >=6 METs; 9. BMI =10% self-reported weight loss in the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VO2 peak; | — |
Secondary
| Measure | Time frame |
|---|---|
| Exercise endurance;Physical activity level;Immune function indicators;Treatment toxicity;Treatment completion;Quality of life and emotional stress; | — |
Countries
China
Contacts
Public ContactHongjuan Li
West China Hospital, Sichuan University
Outcome results
None listed