Cognitive impairment patients
Conditions
Interventions
Acupuncture group:The acupuncture treatment employed the "Tong Du Diao Shen" needling method, selecting acupoints Baihui, Shenting, Yintang, Sishencong, Anmian, Shenmen, Sanyinjiao, Hegu, and Taichong
Sham acupuncture group:Needling was performed only at the epidermal level, selecting acupoints Baihui, Shenting, Yintang, Sishencong, Anmian, Shenmen, Sanyinjiao, Hegu, and Taichong. The treatment cou
rTMS group:The rTMS treatment protocol is as follows:
Stimulation Frequency: 10 Hz.
Stimulation Site: Bilateral precuneus cortex.
Stimulation Intensity: 100% of the resting motor threshold (RMT).
Stim
Sham rTMS group:For the sham rTMS group, the treatment time, stimulated brain region, frequency, and preparation methods are identical to those of the patients receiving real
Sponsors
The Affiliated Brain Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for healthy control group: (1) no complaints of memory disorders; (2) age - and education-matched normal cognitive performance; (3) Clinical Dementia Rating (CDR) = 0. Inclusion criteria for SCD group: Based on the criteria for SCD research published by SCD-I: (1) always complain about their memory problems; (2) subjective cognitive decline questionnaire (SCD-Q) >5; (3) age-and education-matched normal cognitive performance; (4) Activities of daily living were normal.
Exclusion criteria
Exclusion criteria: (1) less than 50 years old or more than 80 years old; (2) patients with contraindications to MRI scanning; (3) years of education: primary school or below; (4) dementia; (5) accompanied by a history of neuropsychiatric diseases, such as cerebrovascular disease, epilepsy, Parkinson's disease, multiple sclerosis, encephalitis, depression, schizophrenia, substance dependence, intracranial tumors and head trauma surgery, accompanied by diseases of the heart, liver, kidney, hematopoietic system and endocrine system that seriously affect cognitive function; (6) Visual and hearing impairment cannot meet the needs of cognitive assessment; (7) More infarcts and microbleeds were found in brain MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of overall cognitive function;Multidimensional assessment of cognitive function;Subjective cognitive decline questionnaire(SCD-Q);Multimodal magnetic resonance imaging (MRI); | — |
Countries
China
Contacts
Public ContactXingjian Lin
The Affiliated Brain Hospital of Nanjing Medical University
Outcome results
None listed