Alzheimer's diasease
Conditions
Interventions
Observation Group:None
Sponsors
Shenzhen people's hospital
Eligibility
Sex/Gender
All
Age
50 Years to 89 Years
Inclusion criteria
Inclusion criteria: 1. Presence of memory decline. 2. Age between 50 and 90 years. 3. Right-handedness. 4. Diagnosis of Alzheimer's disease (AD)-related mild cognitive impairment (MCI) or mild AD dementia according to the criteria established by the National Institute on Aging and the Alzheimer's Association (NIA-AA). 5. Amyloid positivity confirmed by PET imaging or cerebrospinal fluid (CSF) Aß1-42 measurements. 6. Objective impairment in episodic memory, evidenced by a delayed recall score on the Auditory Verbal Learning Test (AVLT) that is more than 1.5 standard deviations below the age-adjusted norm. 7. Montreal Cognitive Assessment (MoCA) score 22. 8. Provision of written informed consent.
Exclusion criteria
Exclusion criteria: 1. Presence of major psychiatric disorders that can lead to cognitive decline (e.g., depression, severe anxiety, significant sleep disorders, schizophrenia), or scores indicating severe anxiety (Hamilton Anxiety Rating Scale \[HAMA] >= 21), or scores suggesting mild to moderate depression (Hamilton Depression Rating Scale \[HAMD] >= 20), or poor sleep quality (Pittsburgh Sleep Quality Index \[PSQI] > 15). 2. Presence of other significant neurological disorders that can cause cognitive decline. 3. Presence of other pathological factors leading to cognitive decline. 4. Cranial MRI showing cerebral infarction, white matter lesions with a Fazekas scale score >= 2, space-occupying lesions, or other significant abnormal signals. 5. Hachinski Ischemic Score > 4. 6. Use of antidepressants, hypnotics, antiepileptic drugs, or similar medications within 4 weeks prior to enrollment. 7. Severe cognitive impairment, language disorders, or inability to cooperate with assessments and examinations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ADS-Cog; | — |
Secondary
| Measure | Time frame |
|---|---|
| rsEEG;MOCA;MMSE;CDR; | — |
Countries
China
Contacts
Public ContactZhou Zhifan
Shenzhen people's hospital
Outcome results
None listed