None
Conditions
Interventions
Propofol group (Group P) :The induction dose in the propofol group was 1.0-2.0 mg/kg (plasma target control concentration 2-3 ug/ml).
Remimazolam group (Group R):The induction dose of remifentanil in this group was 0.2 - 0.3 mg/kg.
Sponsors
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-80 years old, ASA I-III grade; 2. Require open reduction and internal fixation surgery for clavicle or proximal humerus fractures under general anesthesia in beach chair position; 3. Sign the informed consent form and voluntarily participate in this trial.
Exclusion criteria
Exclusion criteria: 1. Have a known allergy to propofol or remimazolam; 2. Have uncontrolled hypertension (systolic blood pressure >= 180 mmHg or diastolic blood pressure >= 100 mmHg); 3. Have preoperative hypotension (systolic blood pressure <= 90 mmHg or mean arterial pressure <= 60 mmHg); 4. Have a history of cerebral infarction, cerebral hemorrhage, or other obvious cerebrovascular diseases with sequelae; 5. Have clear symptoms of upper respiratory tract infection in the past two weeks; 6. Have a diagnosed pulmonary disease (acute asthma attack, chronic obstructive pulmonary disease, pulmonary bullae, etc.); 7. Pregnant or lactating women; 8. Have arrhythmia, significant heart failure, or valvular heart disease before the operation; 9. The investigator considers that the patient is not suitable to participate in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of hypotension during the induction and maintenance phases of anesthesia; | — |
Countries
China
Contacts
Public ContactZhao Yanhua
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed