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The Effects of Mirror Therapy Combined with Transcutaneous Electrical Nerve Stimulation on Limb Function in Stroke Patients and Its Neural Mechanisms: An fNIRS-Based Study

The Effects of Mirror Therapy Combined with Transcutaneous Electrical Nerve Stimulation on Limb Function in Stroke Patients and Its Neural Mechanisms: An fNIRS-Based Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500106450
Enrollment
Unknown
Registered
2025-07-24
Start date
2025-07-28
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

Healthy adults group:Mirror Therapy Combined with Transcutaneous Electrical Nerve Stimulation
Older adults group:Mirror Therapy Combined with Transcutaneous Electrical Nerve Stimulation
Stroke patients group:Mirror Therapy Combined with Transcutaneous Electrical Nerve Stimulation

Sponsors

Fujian Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: The first part of the study: 1. Between the ages of 18 and 65, with more than or equal to 10 years of education, 2. Right-handed, 3. Confirmed by physical examination, it belongs to the category of physical health, and does not have any organic diseases, such as mental illness, epilepsy, neurological diseases, heart, liver, lungs and kidneys, etc., and can cooperate with the completion of the study; 4. Voluntarily participate in this study, and at the same time sign the informed consent form. The second part of the study: 1.65 years old and above, with more than or equal to 10 years of education, 2.right-handed, 3.Confirmed by physical examination, in the category of physical health, without any organic diseases, such as mental illness, epilepsy, neurological diseases, heart, liver, lungs and kidneys and other internal diseases, can cooperate with the completion of the study; 4. Voluntarily participate in this study, and at the same time sign the informed consent form. The third part of the study: 1. The first onset of the disease, the onset time is 2 weeks to 6 months, 2. It meets the requirements of the cerebrovascular diagnosis and classification standards formulated by the Chinese Neuroscience Society and the Neurosurgical Society, 3. There is imaging evidence of brain MRI or CT, 4. Age 50-80 years old, right-handed, 5. Normal hearing, stable condition, clear consciousness; 6. MMSE greater than or equal to 24 points; 7. Able to complete basic wrist flexion and dorsiflexion activities; 8. Self-signed or authorized representative to sign the informed consent form.

Exclusion criteria

Exclusion criteria: The first part of the study: 1. Age greater than 65 years old, or less than 18 years old, 2. Current or previous severe organic or functional diseases, 3. Unable to cooperate with the completion of the study. The second part of the study: 1. Age less than 65 years old, 2. Current or previous severe organic or functional diseases, 3. Unable to cooperate with the completion of the study. The third part of the study: 1. Skull defect, 2. History of stroke, 3. Patients with serious complications, who cannot cooperate with treatment due to repeated conditions, 4. Patients with orthopedic diseases, Parkinson's and other diseases that cause wrist and hand joints to be unable to complete the exercise as required; 5. Infection and damage to the skin of the head; 6. Recurrent seizures of epilepsy.

Design outcomes

Primary

MeasureTime frame
Brain Activation ;Brain functional connectivity;

Countries

China

Contacts

Public ContactZhizhuo Wang

Fujian Medical University

zhizhuow@fjmu.edu.cn+86 188 1080 5137

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026