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The effect of remimazolam on intracranial pressure in patients undergoing laparoscopy in the head-down position: assessed by optic nerve sheath diameter (ONSD) using ultrasonography

The effect of remimazolam on intracranial pressure in patients undergoing laparoscopy in the head-down position: assessed

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500106443
Enrollment
Unknown
Registered
2025-07-23
Start date
2024-11-03
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic operation

Interventions

Group R :Reyentzal was administered as a loading dose of 0.01-0.1 mg/kg intravenously before anesthetic induction, followed by an infusion at a rate of 0.01-0.1 mg-kg-1-h-1 intravenously. Remifentan
Group C:An equal volume of normal saline was administered before anesthetic induction for 10 minutes, followed by continuous infusion at the same rate. The administration of normal saline was disconti

Sponsors

Qingdao University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1. ASA classification: 1 to 2, ensuring the patient is in good health or has mild illness. 2. Age: Adults aged between 20 and 55 years old. 3. Type of surgery: Scheduled to perform a head-down, feet-up laparoscopic surgery at an angle of 15 to 30 degrees. 4. Estimated surgery duration: Not exceeding 3 hours. 5. Informed consent: The patient's family signed the surgical consent form.

Exclusion criteria

Exclusion criteria: 1, patients with body mass index> 30 kg/m^2; 2, uncontrolled hypertension, uncontrolled diabetes, active lung disease, active lung disease, cerebrovascular disease; 3, glaucoma, persistent ocular infection or history of previous ophthalmic surgery; 4, and the actual operation time above 3h.

Design outcomes

Primary

MeasureTime frame
ONSD;

Secondary

MeasureTime frame
Blood pressure;Heart rate;Pulse Oxygenation;End-tidal carbon dioxide;

Countries

China

Contacts

Public ContactQiu Shichao

Qingdao University, Zaozhuang Municipal Hospital

qiushichao0632@163.com+86 185 6323 1603

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026