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High-Intensity Interval Exercise and Low-Carbohydrate Diet for Glycemic Control and Cardiovascular Fitness in Physically Inactive Adults with Prediabetes

High-Intensity Interval Exercise and Low-Carbohydrate Diet for Glycemic Control and Cardiovascular Fitness in Physically Inactive Adults with Prediabetes

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500106438
Enrollment
Unknown
Registered
2025-07-23
Start date
2025-08-01
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

prediabetes

Interventions

High-intensity interval exercise:Perform High-intensity interval exercise (10 × 1-minute run @ 80% HRmax, with 1-minute active recovery @ 50% HRmax) 3 times/week (on non-consecutive days), and maintai
Low-carbohydrate diet:Follow a low-carbohydrate diet prescribed by a registered dietitian. The diet will be carefully designed to ensure that participants receive at least 10% but less than 26% of the
High-intensity interval exercise combined with low-carbohydrate diet:Combining high-intensity interval exercise and a low-carbohydrate diet

Sponsors

Chinese University of Hong Kong - New Territories East Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 64 Years

Inclusion criteria

Inclusion criteria: 1. Middle-aged adults (40-64 years old); 2. Participants will be classified as prediabetic according to the American Diabetes Association diagnostic criteria, which include a threshold value in fasting glucose (5.6–6.9 mmol/L), 2-hour glucose tolerance test (7.8–11.0 mmol/L), or HbA1C (5.7%–6.4%); 3. Physically inactive: less than 3 days of 30-minute moderate-intensity PA per week.

Exclusion criteria

Exclusion criteria: 1. Individuals diagnosed with Type 1 or Type 2 diabetes; 2. Severe health issues known to affect mobility, such as neurologic diseases, musculoskeletal disorders, or autoimmune diseases; 3. Use of specific medications: Individuals currently using medications that affect blood glucose control (such as insulin, certain oral hypoglycemic agents, or steroids); 4. Pregnancy or lactation; 5. Individuals with recent participation in structured exercise or dietary interventions (within 3 months).

Design outcomes

Primary

MeasureTime frame
HbA1c;—

Secondary

MeasureTime frame
2-hour glucose tolerance (OGTT);HOMA-IR;VO2max;Body weight;Body Mass Index (BMI);Body fat;Fat free mass;Waist circumference;Triglyceride;Total cholestrol;High-density lipoprotein cholesterol (HDL-c);Low-density lipoprotein cholesterol (LDL-c);Blood pressure;—

Countries

China

Contacts

Public ContactEric Tsz-chun POON

Chinese University of Hong Kong - New Territories East Hospital

eric.poon@cuhk.edu.hk+852 3943 7157

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026