lower limb fracture
Conditions
Interventions
Improved forgetfulness analgesia slow induction group(study group):Atomization inhalation of 1 % tetracaine was used for surface anesthesia
Slow induction of alfentanil combined with dexmedetomidine
Sponsors
Hefei First People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients undergoing elective lower limb fracture, total hip replacement, total knee replacement and closed reduction of femoral neck fracture; 2.Age >= 60 years old, gender unlimited; 3.BMI ranges from 18 to 24kg/m^2; 4.Fully explain the content of clinical trials, voluntarily join the patient to sign informed consent;
Exclusion criteria
Exclusion criteria: 1.Patients with severe hepatic and renal dysfunction and severe pulmonary hypertension, or severe cardiac insufficiency; 2.Allergic to alfentanil, dexmedetomidine and tetracaine; 3.Patients with mental disorders or mental illness; 4.Patients who refuse to use postoperative analgesia; 5.Patients who participated in other treatment in the last 6 months ( when consent was obtained ); 6.Patients judged to lack the ability to consent; 7.Others, the clinical responsible doctor or clinical in charge of the doctor to judge as inappropriate patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate;Mean arterial pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| recovery;adverse events(intraoperative awareness?postoperative cognitive dysfunction? postoperative delirium);Cough reaction during extubation and sore throat after extubation;recovery;The dosage of etomidate, cis-atracurium and alfentanil during operation;Pulse oxygen saturation;Bispectral index; | — |
Countries
China
Contacts
Public ContactYang Heng
Hefei First People's Hospital
Outcome results
None listed