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Comparison of ED90 of esketamine and fentanil for hysteroscopic analgesia: a randomized controlled trial

Comparison of ED90 of esketamine and fentanil for hysteroscopic analgesia: a randomized controlled trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500106429
Enrollment
Unknown
Registered
2025-07-23
Start date
2025-08-01
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hysteroscopic anesthesia

Interventions

Fentanyl:Fentanyl

Sponsors

zhejiang hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1.Voluntary hysteroscopy; 2.Age 18-60 years old; 3.Body mass index 20-25kg/m^2; 4.ASA stage I-II;

Exclusion criteria

Exclusion criteria: 1.Serious respiratory and circulatory system diseases; 2.Serious neurological and psychiatric disorders; 3.History of drug dependence; 4.Abnormal liver and kidney function; 5.Hearing impairment; 6.Preoperative use of sedatives and analgesics; 7.Individuals allergic to esketamine, fentanyl, and propofol; 8.Contraindications for ketamine, such as patients with refractory, difficult to treat hypertension, severe cardiovascular disease, and hyperthyroidism; 9.Patients who refuse to participate in the study; 10.Patients with surgery time greater than 60 minutes;

Design outcomes

Primary

MeasureTime frame
Propofol usage;ED90 of fentanyl;Postoperative awakening time;staying for PACU time;Doctor and patient satisfaction with anesthesia;Complications;Hospital Anxiety and Depression Scale scores;NRS score;ED90 of esketamine;Intraoperative vital signs (heart rate, mean arterial pressure, systolic blood pressure, diastolic blood pressure, respiratory rate, and pulse oxygen saturation);

Countries

China

Contacts

Public ContactJun Du

zhejiang hospital

vdujun@qq.com+86 571 81595231

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026