acute respiratory distress syndrome (ARDS)
Conditions
Interventions
Control group:PEEP will be titrated using the Pressure-Volume curve method
Experiment Group A:PEEP will be titrated using the OD/CL method
Experiment Group B:Titrate PEEP1 according to the OD/CL method (denoted as PEEP1 for ease of distinction), and then optimize the target PEEP2 based on the optimal V/Q matching strategy
Sponsors
Chongqing hospital of traditional Chinese medicine
Eligibility
Sex/Gender
All
Age
19 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1.Conform to the 2023 A New Global Definition of Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. The diagnostic criteria for ARDS in 2024 (including (1) risk factors and sources of pulmonary edema; (2)Timing of onset; (3)Chest imaging and other three aspects 2.Tracheal intubation with mechanical ventilation and meeting the diagnostic criteria for moderate or severe ARDS; 3.Adequate analgesia, sedation or muscle relaxants are required for treatment; 4.Central venous catheters (internal jugular vein, subclavian vein) need to be inserted due to the condition. (5) Be over 18 years old and under 80 years old; (6) The patient or their family members are willing to sign the informed consent form and participate in the researcher.
Exclusion criteria
Exclusion criteria: 1.Severe obesity with a BMI>40Kg/m^2; 2.There are contraindications for the use of EIT (such as extensive dressing coverage of the chest wall after thoracic surgery, pacemaker implantation, automatic defibrillator implantation in the body, thoracic deformity, extensive damage to the chest wall skin, and extreme emaciation); 3.Terminal stage of tumors and other diseases; 4. The estimated survival time is less than 48 hours; 5. Pregnant and lactating women; 6. Patients with neuromuscular diseases; 7.Where informed consent is lacking or the patient is uncooperative or uncooperative.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pulmonary ventilation distribution;pulmonary blood flow distribution;Ventilation/perfusion matching condition;Airway plateau pressure;Mean airway pressure;Peak airway pressure;Lung compliance;Airway resistance;Positive end-expiratory pressure;oxygen delivery 2;central venous oxygen saturation;Arterial blood lactate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of stay in the Intensive Care Unit;Mechanical ventilation time in the Intensive Care Unit;Offline success rate;APACHE II score results; | — |
Countries
China
Contacts
Public ContactXiangwen Weng
Chongqing hospital of traditional Chinese medicine
Outcome results
None listed