cardiopathy
Conditions
Interventions
Vitamin C group (V group):Vitamin C
Dexmedetomidine (group D):Dexmedetomidine
Vitamin C combined with dexmedetomidine group (VD group):Vitamin C combined with dexmedetomidine
Control group (group C):Normal Saline
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1 Aged from 18 to 70 years old; 2 Cardiac surgery under general anesthesia with cardiopulmonary bypass; 3ASA grade II-III, NYHA grade II-IV.
Exclusion criteria
Exclusion criteria: 1 Acute liver injury existed before operation; 2 emergency operation; 3 Acute or chronic infectious diseases; 4 pregnant women or nursing mothers; 5 severe bradycardia before surgery; 6 neurological and mental disorders; 7 G - 6 - PD deficient; 8 Other situations that do not meet the inclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver function indicators (AST, ALT, direct bilirubin, total bilirubin);Incidence of liver function injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory markers (TNF-a, IL-6);Oxidative stress Index (MDA);Preoperative general information;Intraoperative data (anesthesia time, operation time, cardiopulmonary bypass time, aortic occlusion time, stoppage fluid perfusion times, extracorporeal ultrafiltration volume, intraoperative fluid input volume, urine volume, recurrence mode, operation mode, and intraoperative blood gas analysis indexes, etc.);Postoperative resuscitation and recovery (extubation time, ICU stay and postoperative hospitalization days, postoperative adverse events, etc.); | — |
Countries
China
Contacts
Public ContactFang He
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed