type 2 diabetes
Conditions
Interventions
control group:Maintain the old way of life.
a priori lifestyle intervention group:Lifestyle intervention regimen as prescribed by the guidelines.
data-driven precision intervention group:Evidence-based and data-driven improved and optimized dietary exercise intervention programs.
Sponsors
Harbin Medical University.
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) prediabetes in the age range of 30 to 65 years; (2) diagnosis of prediabetes according to the criteria of WHO 1999 or ADA 2022, including impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and a mixed state of both (IFG+IGT); (3) glycosylated hemoglobin (HbA1c) between 5.7%-6.4%; (4) no serious complications such as cardiovascular and cerebrovascular diseases, kidney diseases, liver diseases, malignant tumors, etc.; (5) BMI between 24.0 and 35.0 kg/m^2; (6) local resident population; (7) willingness to make lifestyle changes, including diet and exercise habits; (8) voluntarily participate in the study and sign the informed consent form;
Exclusion criteria
Exclusion criteria: (1) Patients who have been diagnosed with diabetes mellitus (including type 1 and type 2); (2) Severe endocrine diseases, such as thyroid dysfunction, adrenal gland diseases, etc., endocrine diseases that may affect glucose metabolism; (3) Have serious cardiovascular diseases, such as unstable angina, recent myocardial infarction, severe heart failure, etc.; (4) Exclusion of people with kidney disease and liver disease: (5) Exclusion of disability, cancer or infectious diseases such as tuberculosis and AIDS: (6) Participation in other intervention studies, hypersensitivity to study drugs or methods, other conditions deemed inappropriate by the investigator for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood sugar;blood lipids;blood pressure;gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| weight;Fasting blood glucose;2 hour postprandial blood glucose;Glycosylated hemoglobin;waist circumference;C-reactive protein;Tumor necrosis factor-a;Interleukin-6;Superoxide dismutase;Catalase; | — |
Countries
China
Contacts
Public ContactYucun Niu
School of Public Health, Harbin Medical University.
Outcome results
None listed