Blood system diseases
Conditions
Interventions
Immunonutrition intervention group:Tumor total nutrition formula (Almanit) oral supplement, containing immunonutrients arginine, nucleotides, Omega-3 polyunsaturated fatty acids
Sponsors
The Second Affiliated Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Age
10 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Confirmed diagnosis of hematological diseases (AML/ALL/MDS/AA/MM/NHL/HD); 2. Allogeneic hematopoietic stem cell transplantation is proposed; 3. Age between 10 and 70 years old; 4. Have language communication skills; 5. Willing to cooperate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Inability to take nutrition orally or through tube feeding; 2. Previous history of gastrointestinal surgery or other gastrointestinal treatment that affects nutrient absorption; 3. Other malignant tumors in the past 5 years (except for successfully treated in situ tumors); 4. Subjects have contraindications to enteral nutrition (e.g., active gastrointestinal bleeding, intestinal obstruction, decompensated short bowel syndrome, high-flow intestinal fistula, severe intraperitoneal infection, severe gastrointestinal emptying disorders, unstable vital signs, abnormal coagulation function, severe nausea, vomiting, and/or uncontrolled diarrhea/steatorrhea), and the above symptoms are uncorrectable in the opinion of the investigator; 5. Abnormal liver and kidney function (alanine aminotransferase ALT>=2 times the upper limit of normal value; Total bilirubin Tbil>=2 times the upper limit of normal; Creatinine Cr =2 times the upper limit of normal value); 6. Known history of hypothyroidism or hyperthyroidism; 7. Those who have tuberculosis or human immunodeficiency virus (HIV) infection; 8. Have mental disorders or uncontrolled mental illness 9. Known history of allergy or intolerance to any component of the investigational product; 10. Participated in another interventional clinical study, including nutritional support-related research, within 4 weeks before enrollment; Patients who are not suitable for this study in the opinion of the investigator (such as poor compliance, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of severe malnutrition;Platelet Engraftment time;Neutrophil Engraftment time; | — |
Secondary
| Measure | Time frame |
|---|---|
| One-year OS rate;Transplantation-related mortality;Transplantation-related complications - incidence of acute graft-versus-host disease;Transplant-related complications - incidence of severe oral mucositis;Transplantation-related complications - infection rate; | — |
Countries
China
Contacts
Public ContactQin Weiwei
The Second Affiliated Hospital of Air Force Medical University
Outcome results
None listed