Thyroid surgery
Conditions
Interventions
Group receiving intranasal dexmedetomidine (experimental group) :The experimental group used 0.2 ml of dexmedetomidine nasal spray (100 µg)
Group receiving intranasal saline (control group):The control group patients used 0.2 ml of saline nasal spray
Sponsors
Tianjin First Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing thyroidectomy under general anesthesia; 2. Age 18 ~ 60 years old; 3. ASA is graded as I ~ II; 4. Body mass index (BMI) 18~29 kg/m^2; 5. Patients with informed consent who are willing to participate in this trial.
Exclusion criteria
Exclusion criteria: 1. Contraindications to dexmedetomidine, including allergy or hypersensitivity to other anesthetics of dexmedetomidine; 2. Those who are not suitable for nasal spray administration, such as severe rhinitis and nasal deformity; 3. Sinus heart rate less than 45 beats per minute; 4. Second- or third-degree atrioventricular block; 5. Pregnant or lactating women; 6. Patients taking antihypertensive drugs, such as a-methyldopa, clonidine, or other a 2-adrenergic agonists; 7. Respiratory diseases: severe asthma, severe emphysema, severe bronchitis, severe chronic obstructive pulmonary disease; 8. Liver and kidney insufficiency; 9. Psychopaths; 10. Circulatory system diseases: previous myocardial infarction, unstable angina, severe heart arrhythmia, cardiac insufficiency; 11. Long-term use of sedatives and analgesics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coughing score;incidence of coughing; | — |
Secondary
| Measure | Time frame |
|---|---|
| Riker Agitation-Sedation Scale;Cold rating;Ramsay Sedation Scale Score;mechanical ventilation duration;Time spent in the post-anesthesia recovery room;Wrench cold rating;QoR-15 Score;The satisfaction of anesthesiologists' procedures;Incidence of agitation; | — |
Countries
China
Contacts
Public ContactWeihua Liu
Tianjin First Central Hospital
Outcome results
None listed