Osteoporosis
Conditions
Interventions
Elderly patients with osteoporosis:NA
Control group:NA
Sponsors
the Second Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
70 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1.Inclusion criteria: Elderly patients with osteoporosis (over 70 years old, age may be relaxed if they are menopausal women); 1. Bone density testing (gold standard) Testing method: Dual energy X-ray absorptiometry (DXA) is used to measure the bone density (BMD) of the lumbar spine (L1-L4), femoral neck, or total hip. Diagnostic threshold (based on T-value): T-value = -1.0: Normal bone density. The definition of T-value is the standard deviation (SD) value compared to the average bone density of healthy young adults. 2. History of fragility fractures: If a patient experiences a low-energy traumatic fracture (such as hip, vertebral, or distal radius fracture after a fall), even if the bone density has not reached the osteoporosis threshold (T value <= -2.5), it can be directly diagnosed as "severe osteoporosis".
Exclusion criteria
Exclusion criteria: 1. Chronic diseases and disorders involving important organs (heart, lungs, liver, kidneys, brain); 2. severe metabolic diseases including diabetes, hypoparathyroidism, hyperparathyroidism; 3. other bone diseases including Paget's disease, osteogenesis imperfecta; 4. digestive system diseases such as chronic diarrhea, ulcerative colitis or other chronic diseases causing impaired nutrient absorption; 5. long-term use of drugs that affect bone metabolism such as corticosteroids, anticonvulsants, estrogens, thyroid hormones; 6. women with bilateral oophorectomy. 7. To reduce the influence of other diseases on the number of blood monocytes and gene (protein) expression, the following factors will be excluded from interference: autoimmune or autoimmune-related diseases, immunodeficiency disorders, malignant lesions of blood and lymph, other diseases such as viral infections, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone mineral density (BMD);FSTL1 protein level;Bone tissue FSTL1 mRNA expression level;Vitamin D (25 (OH) D);Parathyroid hormone (PTH); | — |
Countries
China
Contacts
Public ContactBo Lin
the Second Affiliated Hospital of Soochow University
Outcome results
None listed