Lung Cancer
Conditions
Interventions
Intervention group:The intervention group received a two-week preoperative pulmonary rehabilitation program in addition to standard care. Based on individual patient conditions, a home-based exercise
Control group:The control group received standard management, which included routine preoperative assessment, health education, and nutritional support.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Histologically confirmed initially unresectable stage III squamous or non-squamous NSCLC (AJCC 8th edition) before conversion therapy; 2.Completion of >=2–3 cycles of immunotherapy or chemoimmunotherapy for conversion therapy; 3.Multidisciplinary evaluation with imaging (RECIST 1.1) indicating tumor downstaged to resectable status; 4.Age 18–80 years; 5.No contraindications to pulmonary rehabilitation (e.g., myocardial infarction or stroke within 6 months, chronic heart failure, unstable angina, severe arrhythmias, significant left heart dysfunction, acute pulmonary embolism, severe peripheral vascular disease, or limb dysfunction); 6.Voluntary participation with signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Evidence of distant metastasis or concurrent malignancy on imaging; 2.Inability to cooperate (e.g., psychiatric disorder, impaired consciousness, intellectual disability); 3.Intolerance to pulmonary rehabilitation; 4.Presence of contraindications to pulmonary rehabilitation; 5.Other exercise-related contraindications (e.g., active hemoptysis, untreated pneumothorax); 6.Pregnant or lactating participants; 7.Refusal or inability to comply with study procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pulmonary complications (PPCs); | — |
Secondary
| Measure | Time frame |
|---|---|
| Exercise capacity;Physical activity level;Major symptoms;Quality of life and emotional stress; | — |
Countries
China
Contacts
Public ContactGuowei Che
West China Hospital, Sichuan University
Outcome results
None listed