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The Impact of Esketamine on the Incidence of Postoperative Delirium in Elderly Patients with Femoral Fractures: An Observational Cohort Study

The Impact of Esketamine on the Incidence of Postoperative Delirium in Elderly Patients with Femoral Fractures: An Observational Cohort Study

Status
Active, not recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500106356
Enrollment
Unknown
Registered
2025-07-22
Start date
2025-07-31
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative delirium

Interventions

Control group:None

Sponsors

The Affiliated Hospital of Qingdao University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Elderly patients aged 65 years or older who underwent surgery in the Department of Trauma Surgery due to femoral fracture caused by trauma; 2.Normal intellectual and cognitive functions; 3.ASA grade 1-3; 4.Normal MMSE score; 5.No history of mental illness. Participants must be informed of the information related to the trial and sign the research informed consent form.

Exclusion criteria

Exclusion criteria: 1.A history of neurological diseases such as craniocerebral tumors, cerebral hemorrhage, and large-area cerebral infarction, or a history of mental illnesses such as depression and dementia; 2.Severe anxiety and depression after surgery, or severe complications such as pulmonary infection, pulmonary embolism, and cerebral infarction; 3.Currently participating in other experiments or refusing to participate in the experiment; 4.MMSE score <= 26, those allergic to esketamine, etc., and those with dementia.

Design outcomes

Primary

MeasureTime frame
Incidence of delirium;

Secondary

MeasureTime frame
blood glucose;C-reactive protein (CRP);cortisol;lactic acid;Postoperative complications;

Countries

China

Contacts

Public ContactAijie Liu

The Affiliated Hospital of Qingdao University

clara_2074@qdu.edu.cn+86 186 6180 1683

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026