Substance use disorder
Conditions
Interventions
Training Set (Study I):None
Validation Set (Study I):None
Test Set (Study I):None
VR/AR intervention group (Study II):Simulated environment - establish a high-risk environment and situation for narcotic drug use in the virtual world, so that addicts are exposed to situations that m
Trigger Condition Reproduction - Reproduce scenes of previous addictive behaviors in VR to help individuals identify and respond to various trigger situations and enhance self-control ability
Aversion therapy - using the virtual environment to train addicts to combine with the physical and mental harm of narcotic drugs when they are thirsty, and establish a reasonable cognition of drugs
Skill training - including social skills training, refusal skills training, etc., to help individuals build skills to cope with possible relapse behaviors in the real world
Relaxation training – learn relaxation techniques such as meditation and breathing training in a virtual peaceful relaxation environment.
rTMS/tACS intervention group (Study II):rTMS test group: prefrontal cortex, 1Hz, 100% RMT, for 10 minutes, a total of 600 pulses.
tACS test group: Treated with true transcranial intensity AC stimulato
VR/AR control group (Study II):None
rTMS/tACS control group (Study II):rTMS pseudo-stimulation control group: prefrontal cortex, using pseudo-stimulation coils for transcranial magnetic stimulation, subjects will not be subjected to mag
Sponsors
Xiangya Second Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Study 1: 1. Meet the DSM-5 classification criteria for the diagnosis of methamphetamine dependence/abuse; 2. Age 18~55 years old; 3. Patients agree to participate in this project and sign the informed consent form. Study 2: 1. Meet the DSM-5 classification criteria for the diagnosis of methamphetamine dependence/abuse; 2. Age 18~55 years old; 3. Patients agree to participate in this project and sign the informed consent form.
Exclusion criteria
Exclusion criteria: Study 1: 1. Patients with intracranial hypertension, cranial defects, and tumors; 2. Patients with serious physical diseases (such as cardiovascular, liver, kidney, gastrointestinal diseases, etc.), infectious diseases and immune system diseases; 3. History of mental illness before admission; 4. Patients with severe neurological diseases and mental retardation; 5. Those with severe suicidal tendencies; 6.IQ<70 or less than 6 years of education; 7. Currently participating in other assessments or intervention projects; 8. Color blindness and weak color. Study 2: 1. Patients with intracranial hypertension, cranial defects, and tumors; 2. Patients with serious physical diseases (such as cardiovascular, liver, kidney, gastrointestinal diseases, etc.), infectious diseases and immune system diseases; 3. History of mental illness before admission; 4. Patients with severe neurological diseases and mental retardation; 5. Those with severe suicidal tendencies; 6.IQ<70 or less than 6 years of education; 7. Currently participating in other assessments or intervention projects; 8. Color blindness and weak color.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolomics;Severity of addiction;Imaging and electrophysiological data;Cognitive Behavioral Test;Electroencephalogram Physiological Data;Near-infrared data;Metabolomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tobacco use;Alcohol use;Emotion;Sleep;Aggressiveness;Impulsiveness;Personality traits;Traumatic experience;Life satisfaction;Rumination;Sensitivity to punishment and reward; | — |
Countries
China
Contacts
Public ContactHongxian Shen
Xiangya Second Hospital of Central South University
Outcome results
None listed