Advanced Non-Small Cell Lung Cancer in Patients with HIV
Conditions
Interventions
The cohort of advanced NSCLC patients without HIV comorbidity:none
The cohort of advanced NSCLC patients with HIV comorbidity:none
Sponsors
Shanghai Public Health Clinical Center
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.The cohort of advanced NSCLC patients without HIV comorbidity: (1) Age >= 18 years; (2) Advanced NSCLC confirmed by tissue or cytological examination; (3) Not infected with HIV as confirmed by standardized tests; (4) Anti-tumor treatment using immune checkpoint inhibitors combined with chemotherapy. 2. The cohort of advanced NSCLC patients with HIV comorbidity: (1) Age >= 18 years; (2) Advanced NSCLC confirmed by tissue or cytological examination; (3) Confirming HIV infection via standardized diagnostic testing. (4) Anti-tumor treatment using immune checkpoint inhibitors combined with chemotherapy.
Exclusion criteria
Exclusion criteria: 1. For individuals with a history of severe hypersensitivity to monoclonal antibodies. 2. Uncontrolled hepatitis B or C infection, active immunosuppressive therapy, or a history of autoimmune diseases requiring systemic treatment. 3. Idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, or idiopathic pneumonitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Observation of adverse immune events;CD4+T cells;disease control rate, DCR;objective response rate, ORR;progression free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| CD8+T cells;IL-6;HIV viral load;overall survival; | — |
Countries
China
Contacts
Public ContactRuifang Chen
Shanghai Public Health Clinical Center
Outcome results
None listed