None
Conditions
Interventions
R group:Anesthesia induction:Group R was intravenously injected with remazolam besylate 0.3mg/kg (injection time >30s)
Anesthesia maintenance with Remazolam besylate (0.2 ~ 1.0 mg/kg/h)
P group:Anesthesia induction:Intravenous propofol 2 mg/kg (0.5 ml/s) in Group P
Anesthesia maintenance with Propofol (2 to 4 mg/kg/h, group P)
Sponsors
Jinan Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Paients with intravenous aspiration combined under general anesthesia in laparoscopic sleeve gastrectomy wereslective , age 18-60 years, ASAI ~ II, BMI>=30kg/m^2
Exclusion criteria
Exclusion criteria: (1) Preoperative diagnosis of airway difficulties (Mallampati grade =III) or sleep apnea syndrome;(2) severe neuropsychiatric disorders and cognitive dysfunction;(3) Allergic history of benzodiazepines;(4) significant cardiopulmonary instability (heart failure, acute lung injury, hypovolemia or sepsis) and renal or liver dysfunction;(5) Contraindications to remazolam (such as myasthenia gravis, schizophrenia, major depression);(6) have used opioids or benzodiazepines in the past month;(7) Drug or alcohol abuse;(8) Pregnant or breastfeeding patients and women who plan to become pregnant within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score of POD1;Hemodynamic index; | — |
Secondary
| Measure | Time frame |
|---|---|
| quality of recovery;IL-6;TNF-a;GLU;Lactic acid;norepinephrine;Epinephrine;Pain intensity;Adverse drug events; | — |
Countries
China
Contacts
Public ContactRuimei Yuan
Jinan Central Hospital; Central Hospital Affiliated to Shandong First Medical University
Outcome results
None listed