None
Conditions
Interventions
experimental group:Inducing the use of fospropofol disodium combined with remimazolam
control group:Inducing the use of propofol disodium combined with remimazolam
Sponsors
The Ninth Affiliated Hospital of Guangxi Medical University, Beihai People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age 65-85 years old, gender is not limited; 2. American Society of Anesthesiologists (ASA): I.-III. 3. Body mass index (BMI): 18.5~30 kg/m^2; 4. Surgery under general anesthesia is required, and the expected operation time is more than 30 minutes; 5. Voluntarily participated and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those who have contraindications to general anesthesia or have a history of anesthesia accidents in the past; 2. Combined with brain loss, intracranial hypertension, stroke, unstable angina, myocardial infarction; 3. Respiratory insufficiency, obstructive pulmonary disease, difficult airway, or judged to be difficult to intubate (modified Mars score is grade III or IV); 4. Uncontrolled diabetes or hypertension; 5. History of drug abuse, alcohol abuse or drug dependence; 6. Abuse or long-term use of anesthesia, sedative, and analgesic drugs; 7. Known or suspected allergy or contraindication to various components of the study drug or the process medication specified in the protocol (sufentanil citrate injection, remifentanil hydrochloride for injection, phosphopropofol disodium for injection, etc.); 8. Those with a history of mental illness in the past; 9. Those who have participated in any drug clinical trial within 1 month before screening;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of successful cases of anesthesia induction;Time when MOAA/S = 1 minute;Eyelash reflex disappearance time;BIS;mean arterial pressure (MAP);Blood oxygen saturation(SPO2);Pulse pressure anomaly(PPV); | — |
Secondary
| Measure | Time frame |
|---|---|
| Anesthesia duration;operative time; | — |
Countries
China
Contacts
Public ContactZhang Shijing
The Ninth Affiliated Hospital of Guangxi Medical University, Beihai People's Hospital
Outcome results
None listed