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A prospective study to evaluate the alterations of early macular microcirculation following intravitreal injection of faricimab for macular edema secondary to branch retinal vein occlusion

A prospective study to evaluate the alterations of early macular microcirculation following intravitreal injection of faricimab for macular edema secondary to branch retinal vein occlusion

Status
Active, not recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500106303
Enrollment
Unknown
Registered
2025-07-22
Start date
2025-09-01
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Macular edema secondary to branch retinal vein occlusion (BRVO-ME)

Interventions

Experimental group:Intravitreal injection of Faricimab

Sponsors

The Second Affiliated Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Signed informed consent; 2. Age >=18 years old at the time of signing the informed consent form; 3. Male and female patients who have been diagnosed with macular edema secondary to branch retinal vein occlusion (including non-ischemic BRVO and ischemic BRVO); 4. Patients who decide to receive treatment with faricimab and are not related to other studies.

Exclusion criteria

Exclusion criteria: 1. When eligibility is reconfirmed, the patient is not treated with faricimab; 2. Patients who cannot provide OCTA valid data within 2 weeks before receiving the first faricimab injection; 3. The study eye has received any previous faricimab or intravitreal injection of anti-VEGF drugs (including ranibizumab, aflibercept, conbercept, etc.) or intraocular long-acting corticosteroid therapy; 4. The study eye has received any focal or grille-like laser photocoagulation (within 1000um of the fovea) or any PRP treatment in the past; 5. Patients participating in other ophthalmic clinical trials within 28 days before admission; 6. Other situations that the investigator considers unsuitable for participating in this study.

Design outcomes

Primary

MeasureTime frame
Sight;Multifocal Electroretinogram, mfERG;Vascular density in DCP;The density of blood vessels in the SCP;Full - Area Outer Retina, FAOR;Full - Area Central Choroid, FACC;Non - Flow Area, NFA;Foveal Avascular Zone, FAZ;Sub - Retinal Fluid, SRF;Central Sub - foveal Thickness, CST;Intraretinal Fluid, IRF;

Countries

China

Contacts

Public ContactDanning Liu

The Second Affiliated Hospital of Chongqing Medical University

302110@hospital.cqmu.edu.cn+86 23 63693602

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026