Sepsis
Conditions
Interventions
Observation group:None
Sponsors
Affiliated Hospital of Inner Mongolia Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Confirmed infected patients, or suspected infected patients (the definition of suspected infection: (1) acute (within 72 hours) fever or hypothermia; (2) increase or decrease in white blood cell count; (3) increase in CRP, IL-6; (4) increase in PCT, SAA and HBP; (5) definite or suspected infection site. Any two of the above (1)-(4) + the 5th item), with a SOFA score increase of >=2 points compared to the baseline; 2. Sign the informed consent form; 3. Admission to the ICU for less than 24 hours; 4. Age of 18 years or older.
Exclusion criteria
Exclusion criteria: 1. The patient or the patient's family refuses to participate in the trial; 2. The patient or the patient's family requests to withdraw from the trial midway; 3. During the hospital treatment, the patient or the patient's family refuses the doctor's offer of a treatment plan that is helpful for clearing the lesion site; 4. Patients with previous tumor diseases; 5. Patients who have been using immunosuppressants for a long time; 6. Patients who are pregnant; 7. Patients transferred from other hospital's ICU or ICU-like wards.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome of the illness;Duration of blood purification treatment;The duration of invasive ventilator use;The duration of using the non-invasive ventilator;The duration of the use of vasoactive drugs;New cases of pigmentation spots within the first week of admission to the department;New-onset edema cases within the first week of admission to the department;New onset deep vein thrombosis of the lower extremities after admission;New-onset cardiovascular events after admission;New cerebrovascular events after admission;New cases of intestinal necrosis after admission;New cases of limb necrosis occurred after admission;Other vascular embolism events after admission;New onset of gastrointestinal bleeding after admission;New allergic reactions after admission; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine examination;Inflammatory indicators (PCT, IL-6, CRP);Coagulation function + D-dimer;Blood gas analysis;Liver function;Renal function;Myocardial enzymes (creatine kinase, troponin T, lactate dehydrogenase, etc.);BNP;Results of the primary infection pathogen detection;Infection pathogen results within the hospital; | — |
Countries
China
Contacts
Public ContactDagang Yang
Affiliated Hospital of Inner Mongolia Medical University
Outcome results
None listed