knee replacement
Conditions
Interventions
L5-S1 group:Real-time ultrasound-guided spinal anesthesia at the L5-S1 interspace, with intrathecal injection of 15 mg 0.75% bupivacaine, performed for patients undergoing knee arthroplasty.
L3-4 group:Real-time ultrasound-guided spinal anesthesia at the L3-4 interspace, with intrathecal injection of 15 mg 0.75% bupivacaine, performed for patients undergoing knee arthroplasty.
Sponsors
The Affiliated Anning First People's Hospital of Kunming University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. Classified as American Society of Anesthesiologists (ASA) physical status I to III.; 2. Patients scheduled for knee replacement surgery;
Exclusion criteria
Exclusion criteria: 1. Refusal to provide informed consent to participate in the study; 2. Presence of contraindications to spinal anesthesia, including but not limited to: a. Coagulopathy (e.g., international normalized ratio [INR] > 1.5); b. Hemodynamic instability (mean arterial pressure 106 mmHg); c. Elevated intracranial pressure (> 20 mmHg); d. Sepsis; e. Local infection at the puncture site; 3. Severe cardiac disease classified as New York Heart Association (NYHA) class III–IV; 4. Participation in another clinical trial within the past four weeks; 5. Known allergy or hypersensitivity to bupivacaine or any of its components; 6. Body mass index (BMI) > 32 kg/m².
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The highest sensation-blocking plane; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to regression of anesthesia sensory level;Time to the highest blocked spinal segment;Hemodynamic changes during surgery;Usage of vasoactive drugs during surgery;Incidence of postoperative complications;Time to first analgesic rescue after surgery; | — |
Countries
China
Contacts
Public ContactYuekun Liu
The Affiliated Anning First People's Hospital of Kunming University of Science and Technology
Outcome results
None listed