Sepsis
Conditions
Interventions
Sepsis(septic shock) cohorts:None
Sponsors
Xiangya Hospital Central South University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: PART1: 1.The field "Diagnosis Name" contains any of the following terms:"sepsis OR septicemia OR septic shock OR infectious shock OR bloodstream infection OR bacteremia"?? 2.?"Age at Visit" >= 18 years old? 3."Visit Date" is between 2021-01-01 and 2024-04-04? 4.The field "Order Content" contains the term:"intensive care" OR "critical care"?? PART2: 1.Age >= 18 years; 2.ICU stay time > 24h; 3.With the consent of patients or their authorized agent, and signed informed consent. PART3: ?1.Diagnosis:Meets ?Sepsis-3 septic shock diagnostic criteria:(1)Confirmed sepsis (life-threatening organ dysfunction with SOFA score increase >=2 due to infection);(2)Requires vasopressors to maintain ?MAP >=65 mmHg? despite adequate fluid resuscitation;(3)Serum lactate >2 mmol/L?. ?2.Age: ?18–80 years old, both sexes eligible 3.With the consent of patients or their authorized agent, and signed informed consent.
Exclusion criteria
Exclusion criteria: PART1: 1.Missing ?key prognostic data? affecting statistical validity. PART2: 1.Patients with cutaneous lesions (e.g., ulcers, rashes), burns, or active bleeding at the ultrasound measurement site; 2.Patients unable to cooperate due to delirium, agitation, or other behavioral disturbances. PART3: 1.Patients with recurrent sepsis episodes ("second-hit" phenomenon) during disease course; 2.Planned surgical/interventional procedures within 24h post-enrollment that may compromise fluid therapy data quality; 3.Scheduled ECMO initiation within 72h before/after enrollment; 4.Other investigator-determined exclusionary conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ultrasound strain elastography image index;Soft-hard area ratio;28-day all-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liquid intake and output volume;Infusion duration of vasoactive drugs; | — |
Countries
China
Contacts
Public ContactLina Zhang
Xiangya Hospital, Central South University
Outcome results
None listed