Moderate to Severe Traumatic Brain Injury
Conditions
Interventions
The conventional hyperbaric oxygen therapy group:None
The unconventional hyperbaric oxygen therapy group:None
Sponsors
Beijing Chaoyang Hospital , Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1)Based on the medical history, and confirmed by cranial CT scans and clinical symptoms, the diagnosis is traumatic brain injury with a Glasgow Coma Scale (GCS) score of less than 13 points; 2)Aged between 18 and 75 years; 3)The interval from onset of illness to the first session of hyperbaric oxygen therapy is <=3 months; 4)The patient or their family members (for patients with impaired consciousness or cognitive impairment) are aware of this study and voluntarily participate, and all have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1)A history of severe cerebral hemorrhage or cerebral infarction within the past 3 months; 2)Severe dysfunction of vital organs such as the heart, liver, lungs, or kidneys; 3)Malignant tumors, hematologic diseases, or coagulation disorders; 4)A history of mental illness or a family history of mental illness; 5)Pregnant or breastfeeding women; 6)Incomplete clinical data; 7)Currently participating in research studies involving other drugs or medical devices; 8)Spinal cord injury; 9)Recovery of the Glasgow Coma Scale (GCS) score to greater than 13 points within 48 hours after injury.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The DRS scores ; | — |
Secondary
| Measure | Time frame |
|---|---|
| The mRS scores ;Barthel index;all-cause mortality;Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactJing Yang
Beijing Chaoyang Hospital, Capital Medical University
Outcome results
None listed