endometriosis
Conditions
Interventions
Dienogest+PPOS group:1. Dinogest 2mg/day for 28 consecutive days
2. After 28 days, the level of basal hormones (FSH<10 IU/L, E2<50 pg/mL can be initiated).
3. Use letrozole 2.5-5mg/d, combined with HMG225-300IU/d, add dinogest 2mg MPA 4mg to stop MPA on trigger day
PPOS group:Treatment was initiated directly with letrozole 2.5–5 mg/day, HMG 225–300 IU/day, and MPA 4–8 mg/day, following the conventional PPOS protocol
Sponsors
West China Second University Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Age 20-40 years old, planning assisted reproduction and no willingness to transfer fresh embryos (patients who plan to thaw and transfer fertility preservation, PGT or other factors); 2. Diagnosed ovarian endometriosis cyst with a diameter of >=3 cm.
Exclusion criteria
Exclusion criteria: 1. Receipt of other endocrine therapies (such as GnRH-a or contraceptive drugs) within the past 6 months; 2. Presence of other infertility factors (e.g., severe uterine conditions, amenorrhea for >=6 months); 3. Active inflammatory or thrombotic diseases; 4. Contraindications to dienogest (e.g., severe hepatic or renal dysfunction).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| number of oocytes retrieved; | — |
Secondary
| Measure | Time frame |
|---|---|
| total gonadotropin dose;usable embryo rate;cyst diameter;Anti-Müllerian hormone levels; | — |
Countries
China
Contacts
Public ContactHuang Wei
West China Second University Hospital of Sichuan
Outcome results
None listed