Older patients with hypertension
Conditions
Interventions
Intervention group:Anesthesia induction using ciprofol
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Older patients (65–80 years) with hypertension scheduled for elective non-cardiac surgery requiring general anesthesia; 2. American Society of Anesthesiologists (ASA) physical status II or III; 3. Body mass index (BMI) of 18.0–30.0 kg/m^2; 4. Provided written informed consent.
Exclusion criteria
Exclusion criteria: 1. previous diagnosis of cerebral aneurysm or aneurysmal disease involving the thoracic or abdominal aorta; 2. known hypersensitivity to study medications; 3. severe hepatic or renal impairment (Child-Pugh class C or requirement for maintenance dialysis); 4. significant cardiovascular disease, including NYHA functional class III/IV, severe valvular disease, recent (within 6 months) myocardial infarction or unstable angina, frequent ventricular or atrial premature beats, atrial fibrillation, severe bradycardia (heart rate [HR] = 120 mmHg; 8. preoperative hemoglobin concentration < 10 g/dL; 9. known or predicted difficult airway; 10. frailty (FRAIL Scale score 3–5).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-induction hypotension (PIH);Successful induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Peak MAP within 3 minutes after tracheal intubation;Nadir HR during the observation window;Number of administrations of vasoactive drugs;Time from completion of initial ciprofol injection to LoC;The incidence and severity of injection pain;Nadir MAP during the observation window;BIS before tracheal intubation; | — |
Countries
China
Contacts
Public ContactLijian Chen
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed