Abdominal obesity (i.e., central obesity)
Conditions
Interventions
Experimental grou:Add research on new functional food ingredients, healthy diet, and exercise interventions
Control group:Regular healthy diet and exercise intervention
Sponsors
Chinese Academy of Medical Sciences, Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Those who meet the diagnostic criteria of metabolic syndrome (with 3 or more of the following 5 components): (1) Abdominal obesity (i.e. central obesity): waist circumference >= 90cm for men and >= 85CM for women; (2) FPG >= 6.1mmol/l and (or) 2H PG>= 7.8mmol/l, and (or) diagnosed diabetes and treated; (3) Blood pressure >= 130/85mmHg, and/or hypertension has been diagnosed and treated; (4) Fasting TG >= 1.7mmol/l; (5) Fasting hdl-c<1.04mmol/l); 2.Age 18-65 years old; 3.Sign relevant informed consent on a voluntary basis.
Exclusion criteria
Exclusion criteria: 1. Individuals with allergies to food ingredients; 2. Patients with severe digestive or other systemic diseases, such as gastrointestinal diseases causing digestive malabsorption, severe liver and kidney failure, hematological or autoimmune diseases, etc; 3.Patients with active malignant tumors or malignant tumors undergoing treatment; 4.Subjects currently participating in other clinical trials; 5. Pregnant or lactating women; 6. Other populations identified by researchers as unsuitable for participation in this trial, including patients with reduced likelihood of inclusion or complicated inclusion situations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glycosylated hemoglobin;Biochemical indicators of lipid metabolism: total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C); | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin;Metabolome, proteome;Body composition analysis: Body mass index (BMI), body fat percentage, visceral fat area;Liver fibrosis indicators: hyaluronic acid (HA), laminin (LN), type III procollagen (PCII);Inflammatory markers, cytokines;Single cell sequencing and proteomic indicators;Blood uric acid;Liver function (ALT, AST) and kidney function (creatinine, urea nitrogen);Gut microbiota and metabolites; | — |
Countries
China
Contacts
Public ContactChen Wei
Chinese Academy of Medical Sciences, Peking Union Medical College Hospital
Outcome results
None listed