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A Randomized, Controlled, Single-Center Clinical Trial Investigating the Efficacy and Safety of Physical Rehabilitation Therapy on Functional Recovery in Patients Following Knee Arthroplasty

A Randomized, Controlled, Single-Center Clinical Trial Investigating the Efficacy and Safety of Physical Rehabilitation Therapy on Functional Recovery in Patients Following Knee Arthroplasty

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500106172
Enrollment
Unknown
Registered
2025-07-18
Start date
2025-07-30
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis

Interventions

Repetitive transcranial magnetic stimulation group:Stimulation is delivered to the primary motor cortex (M1) of the affected hemisphere using the following parameters: a frequency of 10 Hz administer
Blood flow restriction training group:Conventional rehabilitation training is combined with Blood Flow Restriction (BFR) training. Conventional rehabilitation includes knee flexion/extension exercises
Transcranial direct current stimulation group:Transcutaneous Direct Current Stimulation is combined with quadriceps training. Participants assume a supine position. The center of the cathode electrod

Sponsors

The 958th Hospital of the Chinese People's Liberation Army
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Patients within one month postoperatively after primary unilateral total knee arthroplasty (TKA). 2.Patients who received total condylar arthroplasty (any prosthesis type). 3.Age between 45 and 75 years old (regardless of gender). 4.Absence of brain, heart, lung, or other diseases that impair physical activity. 5.Voluntarily and completely agree to participate in this study. Note: Patients must meet all five criteria above to be included in this study.

Exclusion criteria

Exclusion criteria: 1.Patients with concomitant severe lower limb injuries, such as collateral ligament rupture, fracture, Achilles tendon tear, etc. 2.Patients with a history of anterior cruciate ligament (ACL) or posterior cruciate ligament (PCL) injury in the target knee. 3.Patients with severe comorbidities affecting the cardiovascular, cerebrovascular, hepatic, renal, hematopoietic, or nervous systems, or lumbar spine diseases. 4.Patients with contraindications to electrical stimulation therapy (e.g., cardiac pacemaker, pregnancy, epilepsy). 5.Patients (or their guardians) exhibiting poor compliance or refusing to complete the prescribed treatment protocol. Note: Patients meeting any one of the above criteria will be automatically excluded from this study.

Design outcomes

Primary

MeasureTime frame
Knee injury and Osteoarthritis Outcome Score, KOOS;—

Secondary

MeasureTime frame
Range of Motion, ROM;Knee Society Score, KSS;36-Item Short-Form Health Survey;Tegner Activity Level Scale;Gait parameters;Muscle Strength Testing;Lysholm Knee Score;Surface electromyography parameters;Motor threshold;Balance and Proprioception;Single Leg Hop Test;Dynamic digital radiography parameters;7-Tesla Magnetic Resonance Imaging of the Knee Joint parameters;7-Tesla Functional Magnetic Resonance Neuroimaging parameters;—

Countries

China

Contacts

Public ContactGuo Lin

First Affiliated Hospital of Army Medical University

guolin6212@163.com+86 199 3817 7463

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026