Alcohol dependence
Conditions
Interventions
DLPFC iTBS treatment group:The pulse frequency was 80 % of the resting motion threshold of each subject. Receive iTBS ( 1800 pulses / time, 10 times ).
mPFC cTBS treatment group:The pulse frequency was 110 % of the resting motion threshold of each subject. Accept cTBS ( 1800 pulses / time, 10 times ).
DLPFC iTBS+mPFC cTBS treatment group:Receive iTBS and cTBS combination ( iTBS-900 + cTBS-900 pulse / time, 10 times
randomly assign starting order from iTBS or cTBS ).
TBS pseudo-stimulation treatment group:Using the same parameters, the treatment coil was turned over, and there was no therapeutic effect ( 1800 pulses / time, 10 times, randomly assigned to the appli
Sponsors
The Second Affiliated Hospital of Xinxiang Medical University
Eligibility
Sex/Gender
Male
Age
25 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.Meet ICD-11 diagnostic criteria for alcohol dependence; 2.Male, aged 25 to 45 years, Han nationality, right-handed; 3. Literate in Chinese characters and able to cooperate with the completion of the test; 4.Clinical institute withdrawal assessment - advanced recognised (CIWA-AR) score < 7 points; 5. Fully understand the therapeutic effect of transcranial magnetic therapy and the possible adverse reactions during the treatment; 6. Obtain informed consent from the patient and guardian, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Have severe physical illness or cognitive impairment (e.g., history of head trauma, cerebrovascular disease, epilepsy, etc.), cardiac/intracranial metal implant; 2.Have or have had other mental illness (other than tobacco addiction); 3.Taking medications that affect cognitive function in the past 10 days; 4.The presence of other absolute contraindications to transcranial magnetic stimulation therapy; 5.Poor treatment adherence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Alcohol Use Disorders Identification Test Score;Visual Analogue Scale Score;Penn Alcohol Craving Scale Score;Hamilton Anxiety Scale Score;Hamilton Depression Scale Score;Barratt implusiveness scale score;Pittsburgh sleep quality index;Mini Mental State Examination Score;Digit Span ;TMT-B&W Score;Verbal Fluency; | — |
Countries
China
Contacts
Public ContactShao Zihang
The Second Affiliated Hospital of Xinxiang Medical University
Outcome results
None listed