Infants Lactose Intolerance
Conditions
Interventions
Lactase group:Add lactase to milk
Lactose-free group:Use lactose-free formula feeding
Control group:None
Sponsors
First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Preterm infants who have already been fed enterally (neonates born with a gestational age of = 0.25% or fecal pH <=5.5. 3. Informed consent from the patient's family. 4. Control group neonates (including preterm and term infants): Neonates who have already been fed enterally, with no restrictions on gender or gestational age. 5. Control group neonates (including preterm and term infants): Neonates who have not been fed with lactose-free formula or low-lactose formula before the study.
Exclusion criteria
Exclusion criteria: 1. Infants with congenital malformations or congenital metabolic diseases; infants with neonatal asphyxia (Apgar score <=7). 2. Preterm infants with a confirmed diagnosis of cow's milk protein allergy. 3. Preterm infants who are unable to be fed enterally. 4. Mothers of the infants had specific diseases during pregnancy. 5. Families unwilling to sign the informed consent form and refusing to participate in this study. 6. Control group neonates (including preterm and term infants): Infants with cardiovascular, urinary, digestive, nervous, endocrine, congenital diseases, and acute or chronic infectious diseases. 7. Control group neonates (including preterm and term infants): Families of the infants refuse to participate in this project. 8. Control group neonates (including preterm and term infants): Infants diagnosed with neonatal lactose intolerance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CR Rate;PR Rate;OR Rate;AE Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in oral microecology;Changes in the intestinal microecology;Changes in metabolomics of blood and urine ;The influence on growth and development; | — |
Countries
China
Contacts
Public ContactYu Muxue
First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed