None listed
Conditions
Interventions
Ciprofol group:Intravenous sufentanil 0.1 µg/kg was pushed at the beginning of anaesthesia, and 2 min later the test preset dose of ciprofol was pushed intravenously.The initial dose was 0.4 mg/kg, an
conversely, if the previous patient experienced the above reactions), the dose of ciprofol was increased by one gradient.
Propofol group:Intravenous sufentanil 0.1 µg/kg was pushed at the beginning of anaesthesia, and 2 min later intravenous propofol was pushed at the preset dose for the test.The initial dose was 1.5 mg/
conversely, if the previous patient experienced the above reactions), the dose of propofol was increased by one gradient.
Sponsors
Hangzhou Red Cross Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. patients with proposed painless gastroscopy who meet the criteria for the procedure; 2. aged 18~65 years old, BMI 18.5~23.9kg/m2; 3. ASA Class I or Class II, NYHA Class I or Class II; 4. no obvious abnormality in the preoperative examination; 5. no difficult airway as assessed preoperatively; 6. no pharyngeal diseases such as laryngeal edema or pharyngeal swelling.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or breastfeeding; 2. contraindication to general anesthesia or history of anesthetic accident; 3. allergy to or contraindication to cypropofol, opioids; 4. having serious heart, lung, liver, kidney, brain and other major diseases; 5. abuse or long-term use of anesthesia, sedative, analgesic drugs; 6. have a mental illness or inability to communicate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ED50 of ciprofol or propofol during gastroscopy in both groups.;bradycardia (HR 30 s); | — |
Secondary
| Measure | Time frame |
|---|---|
| MAP;HR;SpO2; | — |
Countries
China
Contacts
Public ContactDeying Kang
Hangzhou Red Cross Hospital
Outcome results
None listed