Peutz - Jeghers Syndrome
Conditions
Interventions
Ciprofol group:During induction, administer Cypofol at a dose of (0.4 - 0.5 mg/kg),Infuse Cypofol by infusion pump at a rate of 0.8 - 2.4 mg /(kg/h).
Propofol group :During induction, administer Propofol at a dose of (1.5 - 2.5 mg/kg),Infuse Propofol by infusion pump at a rate of 4 - 12 mg/(kg/h).
Sponsors
Air Force Characteristic Medical Center
Eligibility
Sex/Gender
All
Age
14 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with intestinal polyps of Peutz-Jeghers syndrome (PJS); 2. Aged between 14 and 65 years old, with a body mass index (BMI) of >=18 and <30 kg/m²; 3. American Society of Anesthesiologists (ASA) physical status classification of grade I to III; 4. The surgical method is transoral painless enteroscopy examination or treatment; 5. The anesthesia method is general anesthesia with tracheal intubation; 6. Stable vital signs and accompanied by family members during the visit; 7. Willing to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Have a history of long-term use of opioid drugs; 2. Be complicated with severe diseases of the heart, liver, kidney, etc.; 3. Be complicated with organ damage caused by hyperglycemia in patients with diabetes mellitus; 4. Have experienced major surgeries recently; 5. Have difficulties in airway management, such as severe facial deformities, temporomandibular joint ankylosis, ankylosing spondylitis, etc.; 6. Have infections in the throat, decreased lung compliance, or respiratory tract bleeding; 7. Have a high risk of vomiting, regurgitation, and aspiration, such as not fasting, a full stomach, excessive intra-abdominal pressure, pregnancy over 14 weeks, intestinal obstruction, and hiatal hernia; 8. Lack the ability to take care of themselves and are not fully capable of civil conduct; 9. Show resistance to enteroscopy examination; 10. Be patients with a history of severe allergies, mental diseases, or psychological disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Incidence of Hypotension in Patients during Anesthesia Induction and Maintenance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of hypotension;Arterial pressure during hypotensive episodes;The mean arterial pressure at the occurrence of hypotension;The Incidence of Bradycardia;The Frequency of Use of Vasoactive Drugs;The Total Amount of Vasoactive Drugs During the Operation;The Lowest Blood Pressure During the Operation;Results of Blood Gas Analysis;Plasma Cortisol Level;Plasma Norepinephrine Level;Recovery Time;Extubation Time;Post - extubation Post - operative Gastrointestinal Function I - FEED Score;Post - operative Gastrointestinal Function I - FEED Score at 1 Day after Surgery;The Patient's Mini - Mental State Examination Score One Day Before Surgery;The Patient's Mini - Mental State Examination Score One Day After Surgery; | — |
Countries
China
Contacts
Public ContactYe Bo
ACharacteristic Medical Centerir Force
Outcome results
None listed