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Efficacy of Doxycycline Combined with Fuke Qianjin Capsule in Treating Chronic Endometritis in Assisted Reproductive Patients: A Randomized Controlled Trial on Clinical Outcomes and Pregnancy Success

Doxycycline plus Fuke Qianjin Capsule for Chronic Endometritis in Infertile Women Undergoing ART: A Randomized Trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500106121
Enrollment
Unknown
Registered
2025-07-17
Start date
2025-07-30
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Endometritis

Interventions

Control group:The control group received doxycycline 100mg twice daily (bid) for 14 days,
experimental group: the experimental group received doxycycline 100mg bid for 14 days plus Fuke Qianjin Capsule (2 tablets bid for 14 days).

Sponsors

West China Second University Hospital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 38 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 20 to 38 years old who have undergone IVF/ICSI fertility in our hospital; 2. Previous transplant failure> = 1 time 3. Patients who underwent hysteroscopy and endometrial biopsy before transplantation, and were confirmed by pathological examination to have chronic endometritis.

Exclusion criteria

Exclusion criteria: 1. Abnormal uterine development, such as mediastinal uterus, unicornuate uterus, double uterus, etc.; 2. Endometrial lesions, such as endometrial hyperplasia, intrauterine adhesions, submucosal fibroids, endometrial polyps; 3. Untreated hydrosalpinx. 4. Patients with acute inflammation of the reproductive system. 5. Patients with abnormal immunity, such as anticardiolipid syndrome, immune disorders, etc.

Design outcomes

Primary

MeasureTime frame
clinical cure rate of chronic endometritis";

Secondary

MeasureTime frame
Endometrial thickness on the day of embryo transfer;Pregnancy outcomes(Clinical pregnancy rate,Miscarriage rate,Live birth rate);

Countries

china

Contacts

Public ContactWei Huang

West China Second University Hospital of Sichuan University

weihuang64@163.com+86 181 8060 9196

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026