Postoperative nausea and vomiting
Conditions
Interventions
Control Group:normal saline was added to the patient-controlled intravenous analgesia
0.4g VitB6 group:0.6g/12ml of vitamin B6 injection was added to the patient-controlled intravenous analgesia
0.6g VitB6 Group:0.6g/12ml of vitamin B6 injection was added to the patient-controlled intravenous analgesia
Sponsors
Third Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients deemed necessary to use and voluntarily using patient-controlled intravenous analgesia pumps under physician evaluation; 2. Age 18–80 years, with capacity to provide informed consent; 3. ASA Class I–III.
Exclusion criteria
Exclusion criteria: 1. Known allergy to VitB6 or use of VitB6 within one week before surgery; 2. Use of long-acting antiemetics or emetics within one week before surgery; 3. Long-term use of opioids or glucocorticoids; 4. Presence of other conditions that may cause nausea and/or vomiting, such as hepatitis or gastric ulcers; 5. Postoperative gastric tube management; 6. Pregnancy or lactation; 7. Intellectual disability, mental illness, or severe neurological disease; 8. Refusal to participate in this study or participation in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative nausea and vomiting within 48 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative nausea within 48 hours;Severity of PONV (0 none; 1 mild; 2 medium; 3 violent);Incidence of postoperative vomiting within 48 hours;Frequency of vomiting;Time to first onset of postoperative nausea and vomiting;Nausea relief time;Rescue antiemetic drugs;Maximum pain score at 12 hours/24 hours postoperatively;24-hour resting/move pain score;24-hour/48-hour analgesic pump usage;Patient-controlled number of doses per dose;Length of hospital stay; | — |
Countries
China
Contacts
Public ContactLe Yuan
Department of Anesthesiology, Third Xiangya Hospital, Central South University
Outcome results
None listed