The 50% effective dose of esketamine to sevoflurane was measured by modified Dixon's up-and-down method in children under 1 year of age

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500106115

Enrollment

Unknown

Registered

2025-07-17

Start date

2025-08-01

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None

Interventions

A group:The dose of Esketamine was 0.5mg/kg

B group:The dose of Esketamine was 0.8mg/kg

C group:The dose of Esketamine was 1.0mg/kg

Eligibility

Sex/Gender

All

Age

No minimum to 1 Years

Inclusion criteria

Inclusion criteria: children under 1 year old who underwent elective surgery in general anesthesia, the ASA grade was I-II

Exclusion criteria

Exclusion criteria: 1. Children with premature birth 2 Have a respiratory infection within two weeks; 3 Contraindicate the use of sevoflurane and esketamine; 4 Not obtaining informed consent.

Design outcomes

Primary

Measure	Time frame
the effective concentration of sevoflurane;	—

Countries

China

Contacts

Public ContactWei xiaoyong

Maternal and child health hospital of henan province The third affiliated hospital of zhengzhou university

haopeipei0311@163.com+86 130 8366 5959

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026