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A prospective study comparing the clinical value of pathogen-targeted sequencing (tNGS) of target lesion tissue and alveolar lavage fluid from the drainage area in patients with severe/failed primary community-acquired pneumonia

A prospective study comparing the clinical value of pathogen-targeted sequencing (tNGS) of target lesion tissue and alveolar lavage fluid from the drainage area in patients with severe/failed primary community-acquired pneumonia

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500106109
Enrollment
Unknown
Registered
2025-07-17
Start date
2025-07-25
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe/failed primary community-acquired pneumonia

Interventions

Observation group:None

Sponsors

The First Affiliated Hospital of Soochow University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age >=18 years. 2.Diagnosis meeting either: severe community-acquired pneumonia (SCAP) or treatment-refractory community-acquired pneumonia (CAP). 3.Willingness to undergo bronchoscopy. 4. Written informed consent provided by the patient or their legally authorized representative.

Exclusion criteria

Exclusion criteria: 1.Long-term residence in nursing homes. 2. Post-tracheostomy status. 3.Initial admission for CAP but subsequent ICU transfer due to hospital-acquired pneumonia (HAP) exacerbation. 4.Contraindications to bronchoscopy. 5. Failure to complete bronchoscopy within 72 hours of admission. 6.Concurrent participation in other clinical trials.

Design outcomes

Primary

MeasureTime frame
Responsible pathogens detected by NGS;Optimised antimicrobial regimens based on responsible pathogens;—

Countries

China

Contacts

Public ContactCheng Chen

The First Affiliated Hospital of Soochow University

chencheng@suda.edu.cn+86 137 7177 5292

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026