Common mental disorders: Schizophrenia, Bipolar disorder, Major depressive disorder, Anxiety disorders, Obsessive-compulsive disorder, Intellectual disability
Conditions
Interventions
Control:None
Sponsors
Renmin Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
10 Years to 60 Years
Inclusion criteria
Inclusion criteria: Diagnosed with common mental disorders (per DSM-5 and SCID-I/P structured interviews), including: Schizophrenia Bipolar disorder Major depressive disorder Anxiety disorders Obsessive-compulsive disorder Intellectual disability Age: 10–60 years old Ethnicity: Han Chinese Provided informed consent for study participation. Healthy Control Group: Screened using SCID-N-I/P to confirm absence of psychiatric disorders.
Exclusion criteria
Exclusion criteria: Presence of organic brain diseases or traumatic brain injury. Severe systemic conditions, including: Cardiac: Severe arrhythmias, heart failure. Respiratory: Respiratory failure. Neurological: Epilepsy. Endocrine: Thyroid storm or myxedema crisis. Hepatic: Hepatic encephalopathy. Gastrointestinal: Active gastrointestinal bleeding. Renal: Renal failure. Oncologic: Malignant tumors. History of alcohol or substance dependence. Pregnancy or lactation. Contraindications for cranial MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI;Functional near-infrared spectroscopy;Facial expression;Speech feature;Electroencephalogram;MATRICS Consensus Cognitive Battery, MCCB;Electrocardiograph;blood routine examination;blood biochemistry; Niacin skin flushing response, NSFR; DNA methylation; green space area;PM 2.5;Generalized Anxiety Disorde-7, GAD-7;Pittsburgh sleep quality index, PSQI;Snaith-Hamilton Pleasure Scale,SHAPS;Interpersonal Relationship Comprehensive Diagnosis Scale;Childhood Trauma Questionnaire,CTQ;Patient Health Questionnaire-9,PHQ-9;Big Five Personality;Hypomania Checklist,HCL-32;Egna Minnen Betraffande Uppfostran, EMBU;Dysfunctional Attitudes Scale,DAS;Insomnia Severity Index,ISI;Social Support Rating Scale, SSRS;Mood Disorder Questionnaire, MDQ;Non-suicidal self-injury,NSSI;Ottawa self-injury inventory,OSI;Hamilton Anxiety Rating Scale,HAMA;Hamilton Depression Rating Scale,HAMD;Brief Psychiatric Rating Scale,BPRS;Young Mania Rating Scale,YMRS;Positive and negative syndrome scale,PANSS;ozone;noise levels;wind speed;air temperature;Relative humidity;light pollution;Human micro-environment, Surface pressure;medical record;Demographic information; | — |
Countries
China
Contacts
Public ContactXiaofen Zong
Renmin Hospital of Wuhan University
Outcome results
None listed