Complete onset of muscle relaxation and complete recovery
Conditions
Interventions
Esketamine group (ES group):Intravenous injection of 0.25mg/kg esmketamine was administered
Normal saline group (NS group):An equal volume of normal saline was administered intravenously
Sponsors
The Second Affiliated Hospital of Shantou University Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. ASA grading I-II; 2. Age 18-64 years old; 3. Elective surgery, tracheal intubation and general anesthesia, estimated operation time 1-4h; 4.18.5<=BMI<30; 4. Able to understand the trial and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Abnormal intraoperative body temperature (>37.5 or 4h or blood loss> 600ml; 4. Preoperative disorders of water, electrolyte and acid-base balance; 5. Previous trauma or disability of the proposed parts of both hands; 6. Those who are found to have suspected allergic reactions to the study drug or other anesthetic drugs; 7. Women who are pregnant or lactating or have a birth plan for 6 months (including men); 8. Lesions of important organs or organs (heart, brain, liver, kidneys or lungs) before surgery; 9. Untreated or poorly controlled hypertension (>=180/110mmHg) or diabetes mellitus (fasting blood glucose>=8.0) before surgery; 10. Comorbid psychiatric or neuromuscular system diseases; 11. Preoperative use of calcium channel blockers, aminoglycoside antibiotics or phenytoin sodium and other drugs that affect the strength and/or duration of muscle relaxants; 12. Patients who are unwilling to participate in the trial, who have lost their clinical data, and who are judged by other investigators to be unsuitable to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Onset time of muscle relaxation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters (heart rate, mean blood pressure);Incidence of adverse reactions;Tracheal intubation condition score;Muscle relaxation recovery index; | — |
Countries
China
Contacts
Public ContactZhang Yongfa
The Second Affiliated Hospital of Shantou University Medical College
Outcome results
None listed