Cerebral hemorrhage
Conditions
Interventions
rPNMS+rTMS group:rPNMS+rTMS
rPNMS+ sham rTMS group:rPNMS+ sham rTMS
sham rPNMS+rTMS:sham rPNMS+rTMS
Sponsors
Guangdong Sanjiu Brain Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with chronic consciousness disorder caused by intracerebral hemorrhage, the diagnosis conforms to the Chinese Expert Consensus on the Diagnosis and Treatment of Chronic Consciousness Disorder (Chinese Journal of Neurology, 2020) of the Chinese Medical Doctor Association; 2. Diagnosis of VS or MCS according to the Revised Coma Recovery Scale (CRS-R); 3. The course of the disease is 3~6 months, the first onset of the disease and the clinical symptoms are stable; 4. No obvious cerebral edema and no severe cerebral atrophy; 5. 18 years old< = age< = 70 years; 6. No skull defect, no infection, no bleeding point, no damage at the stimulation site; 7. The legal guardian agrees and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with unclear diagnosis in pre-screening assessment and fluctuating diagnosis in baseline assessment; 2. Presence of contraindications to treatment such as pacemaker, skull repair surgery, metal brain implant or nerve stimulator; 3. Patients taking sedative medications and Na or Ca2 channel blockers or NMDA receptor antagonists to avoid interactions with the putative neuromodulatory effects of rTMS; 4. Those who are undergoing neuromodulation therapy such as TMS and vagus nerve stimulation; 5. History of epilepsy, psychiatric disease, neurodegenerative disease or drug abuse and alcoholism; 6. Other diseases that cause consciousness disorders, such as severe acute infection, endocrine and metabolic disorders, cerebral mass diseases, and water and electrolyte balance disorders; 7. Patients with a tendency to recurrent intracerebral hemorrhage; 8. There are factors that affect the alteration of consciousness (high or low blood sugar, electrolyte imbalances, infections, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coma recovery scale-revised Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glasgow Coma Scale Score;Brainstem auditory evoked potential;Upper somatosensory evoked potential; | — |
Countries
China
Contacts
Public ContactChen Hanbo
Guangdong Sanjiu Brain Hospital
Outcome results
None listed