Septic shock
Conditions
Interventions
Experimental group:Standard treatment and methylene blue at a loading dose of 2.0mg/kg +0.5mg/kg/h was maintained for 24 hours.
Control group:Standard treatment for spetic shock.
Sponsors
Mindong Hospital of Fujian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years; 2.Diagnosed as septic shock based on of Sepsis-3 definition; 3.Patients who requiring a continuous infusion of norepinephrine greater than 0.5 ug/kg/min or an equivalent dose of other vasopressors to maintain mean arterial pressure (MAP) greater than 65 mmHg; 4.Patient or guardian has signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1.Pregnant or lactating women; 2.Patients allergic to methylene blue; 3.Glucose 6-phosphate dehydrogenase deficiency; 4.Patients participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sublingual microcirculation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin Mottling Score;Capillary Refill Time;Vasoactive drugs;Central venous oxygen saturation;Mean arterial pressure; | — |
Countries
China
Contacts
Public ContactHuogen Lliu
Mindong Hospital of Fujian Medical University
Outcome results
None listed